Long Non-coding RNAs (lncRNAs), A New Target in Stroke
Ziyu Wang1, Xiang Li1, Liangliang Huang1
1State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Cellular and Molecular Neurobiology
|September 1, 2020
Summary
Long non-coding RNAs (lncRNAs) show altered expression after stroke, impacting key pathological processes. Understanding these lncRNAs offers potential for improved stroke prediction and treatment.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Stroke is a leading cause of disability and mortality globally.
- Understanding stroke pathophysiology at cellular and molecular levels is crucial.
- Aberrant expression of long non-coding RNAs (lncRNAs) is observed post-stroke.
Purpose of the Study:
- To review and summarize 35 lncRNAs associated with stroke.
- To elucidate the functional roles of these lncRNAs in stroke prognosis.
- To explore their potential as predictive biomarkers and therapeutic targets.
Main Methods:
- Literature review and synthesis of existing research on lncRNAs and stroke.
- Analysis of lncRNA functions in stroke-related pathological processes.
- Evaluation of lncRNA expression patterns and their correlation with stroke outcomes.
Main Results:
- Identified 35 specific lncRNAs implicated in stroke.
- Demonstrated lncRNA involvement in apoptosis, inflammation, angiogenesis, and autophagy.
- Highlighted the signaling pathways modulated by these lncRNAs.
Conclusions:
- lncRNAs play significant roles in the molecular mechanisms of stroke.
- These lncRNAs hold promise as biomarkers for stroke prediction.
- Targeting lncRNAs may lead to more effective and safer stroke treatments.
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