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Published on: February 12, 2017
Intensity-modulated Radiation Therapy for Lymph Node Oligo-recurrence
Akiko Sato1,2, Motoko Omura3, Yumiko Minagawa3
1Department of Radiation Oncology, Shonan Kamakura General Hospital, Kamakura, Japan akikosato.tk@gmail.com.
Background/Aim:
This study aimed to evaluate the effect of intensity-modulated radiation therapy (IMRT) on the clinical outcomes of patients with lymph node (LN) oligo-recurrence and a controlled primary tumor.
Patients And Methods:
We retrospectively reviewed the medical records of 21 patients diagnosed with LN oligo-recurrence who received IMRT with curative intent. Patients with tumor of various primary sites and histopathological types were included in this study.
Results:
The 3-year overall survival (OS) and in-field progression-free survival (PFS) rates were 75% and 52%, respectively. Statistical analysis showed that lower dose to the gross tumor volume (GTV) and larger GTV were significantly associated with poorer OS; adenocarcinoma and lower dose to GTV were significantly associated with poorer in-field PFS. No patients experienced severe adverse events.
Conclusion:
IMRT may provide a safe and effective treatment for patients with LN oligo-recurrence. Tumor dose-escalation sparing normal tissue using IMRT technology may improve the OS and in-field PFS.
