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Pregnancy and COVID-19: management and challenges
Yao Wenling1,2, Qiu Junchao3, Zhirong Xiao3
1Department of Infectious Diseases, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Revista Do Instituto De Medicina Tropical De Sao Paulo
|September 3, 2020
Summary
Pregnant women infected with COVID-19 may face pregnancy complications due to immune responses. While vertical transmission is unproven, maternal deaths are increasing, highlighting the need for special attention to pregnant women and neonates.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pathology
Background:
- COVID-19 in pregnancy presents risks, including potential vertical transmission.
- Limited understanding necessitates comprehensive reviews on COVID-19's impact on pregnant individuals.
Purpose of the Study:
- To review current research on COVID-19 in pregnancy, focusing on clinical features, outcomes, and placental pathology.
- To compare SARS-CoV-2 with SARS-CoV and MERS-CoV in pregnant women.
Main Methods:
- Literature review of recently published studies and official documents.
- Comparative analysis of clinical features, pregnancy outcomes, and placental histopathology.
Main Results:
- SARS-CoV-2, SARS-CoV, and MERS-CoV can trigger cytokine storms and immune responses, potentially causing pregnancy complications.
- ACE2 receptor expression in placental vasculature may explain observed placental changes.
- Clinical presentation in pregnant women with COVID-19 pneumonia mirrors non-pregnant individuals.
Conclusions:
- No definitive evidence of intrauterine vertical transmission of SARS-CoV-2, SARS, or MERS exists.
- Increasing maternal deaths due to COVID-19 underscore the critical need for focused prevention, diagnosis, and management strategies for pregnant women and neonates.
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