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Updated: Dec 10, 2025

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Recent developments in the use of fluorine NMR in synthesis and characterisation
1Syngenta, Jealott's Hill Research Centre, Bracknell, Berkshire RG42 6EY, UK.
Abstract:
A review of developments in fluorine NMR of relevance to synthesis, characterisation and industrial applications of small organic molecules. Developments considered include those in spectrometer technology, computational methods and pulse sequences. The review of 80 references outlines applications in areas of identification, quantitation, mixture analysis, reaction monitoring, environmental studies and fragment-based drug design.
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