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Premenstrual changes. Impaired hormonal homeostasis.
1Affective Disorders Program at Affiliated Hospitals, State University of New York, Buffalo.
Endocrinology and Metabolism Clinics of North America
|March 1, 1988
Summary
Premenstrual changes (PMCs) are common but poorly understood. Research suggests PMCs may stem from temporary homeostatic imbalances caused by fluctuating hormone levels during the luteal phase.
Area of Science:
- Reproductive endocrinology
- Neuropsychiatry
- Systems biology
Background:
- Premenstrual changes (PMCs) in mood and behavior are highly prevalent.
- The underlying pathophysiology of PMCs remains largely unknown.
- Currently, no definitive treatments for PMCs are established.
Purpose of the Study:
- To explore the potential causes of premenstrual changes.
- To investigate the role of hormonal fluctuations in PMCs.
- To suggest a theoretical framework for understanding PMC pathophysiology.
Main Methods:
- Review and synthesis of existing scientific literature on PMCs.
- Analysis of data concerning hormonal and physiological changes during the luteal phase.
- Evaluation of homeostatic mechanisms in relation to cyclical changes.
Main Results:
- Premenstrual changes are suggested to arise from temporary homeostatic disruptions.
- These disruptions are linked to the varying rates and degrees of hormonal shifts during the luteal phase.
- A multitude of bodily systems may be involved in these homeostatic impairments.
Conclusions:
- PMCs may result from a transient breakdown in the body's overall balance.
- Hormonal dynamics during the luteal phase are implicated as a key trigger.
- Further research is needed to elucidate the precise mechanisms and develop effective treatments.