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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Functions of the Lymphatic and Immune System01:28

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
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Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Related Experiment Video

Updated: Dec 9, 2025

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

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Imaging technology of the lymphatic system.

Anna K Polomska1, Steven T Proulx2

  • 1ETH Zürich, Institute of Pharmaceutical Sciences, Vladimir-Prelog Weg 1-5/10, 8093 Zürich, Switzerland.

Advanced Drug Delivery Reviews
|September 6, 2020
PubMed
Summary

Advanced lymphatic imaging techniques improve visualization of lymphatic vessels and function. This review covers current clinical methods, new preclinical technologies, and quantification approaches for diagnosing lymphatic disorders and evaluating therapies.

Keywords:
ContractilityLymph nodeLymphangiographyLymphatic systemLymphatic vesselLymphscintigraphyMRINIR fluorescenceTracer

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Related Experiment Videos

Last Updated: Dec 9, 2025

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Published on: March 8, 2013

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Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
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Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

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Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
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Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

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Area of Science:

  • Biomedical imaging
  • Lymphatic system research
  • Pathology diagnostics

Background:

  • The lymphatic system is crucial for fluid balance, immunity, and implicated in diseases like lymphedema, cancer metastasis, and inflammation.
  • Current clinical lymphatic imaging techniques have limitations.
  • Understanding lymphatic function is vital for disease management.

Purpose of the Study:

  • To review the current state of clinical lymphatic imaging.
  • To highlight recent advancements in lymphatic imaging technology for preclinical models.
  • To discuss methods for quantifying lymphatic function and emerging clinical applications.

Main Methods:

  • Review of existing clinical lymphatic imaging modalities.
  • Analysis of recent progress in imaging technology, including novel tracer design and injection techniques.
  • Description of developing approaches for quantifying lymphatic function.

Main Results:

  • Existing clinical lymphatic imaging techniques have specific advantages and disadvantages.
  • New preclinical imaging technologies offer excellent spatial and temporal resolution for visualizing lymphatic vessels.
  • Various methods are being developed to quantify lymphatic system function.

Conclusions:

  • Continued innovation in lymphatic imaging is essential for improving diagnostic accuracy for lymphatic disorders.
  • Advanced imaging will facilitate the evaluation of new therapies targeting the lymphatic system.
  • Emerging topics in lymphatic imaging hold promise for future clinical applications.