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Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Mechanism of Lamellipodia Formation01:31

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
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Cis-regulatory Sequences02:02

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Mechanism of Filopodia Formation01:39

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Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Updated: Dec 9, 2025

Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum
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Pattern regulation in a regenerating jellyfish.

Chiara Sinigaglia1, Sophie Peron1, Jeanne Eichelbrenner1

  • 1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), Villefranche-sur-mer, France.

Elife
|September 7, 2020
PubMed
Summary
This summary is machine-generated.

Jellyfish regeneration rapidly restores shape and function through mechanical forces and cell movements. Local interactions guide patterning, particularly for the central feeding organ, highlighting a novel regenerative mechanism.

Keywords:
Clytia hemisphaericaCnidariaHydrozoadevelopmental biologyjellyfishmedusaregenerationregenerative medicinestem cells

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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

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Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Marine Biology

Background:

  • Jellyfish possess tetraradial symmetry, offering unique insights into biological patterning.
  • Understanding regeneration mechanisms is crucial for regenerative medicine and developmental biology.

Purpose of the Study:

  • To investigate the mechanisms underlying rapid regeneration in jellyfish fragments.
  • To elucidate the roles of mechanical forces, cell behaviors, and signaling pathways in restoring form and function.

Main Methods:

  • Fragmentation of jellyfish specimens.
  • Analysis of actomyosin-based remodeling and cell migration.
  • Gene expression analysis (Wnt6).
  • Investigation of Wnt/β-catenin signaling pathway.

Main Results:

  • Jellyfish fragments rapidly restore shape and functionality, including the central feeding organ (manubrium).
  • Actomyosin-powered remodeling and cell convergence around 'hubs' establish positional landmarks.
  • Wnt6 expression and stabilization of hubs depend on muscle fiber configuration.
  • Manubrium regeneration is Wnt/β-catenin dependent, involving proliferation and cell recruitment.

Conclusions:

  • Jellyfish regeneration relies on an interplay of mechanical forces, cell migration, and proliferation.
  • Local interactions, driven by remodeling, are key to body patterning during regeneration.
  • The study reveals a novel paradigm for regeneration, applicable to understanding complex biological patterning.