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Related Experiment Video

Updated: Dec 9, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Modular Reconfigurable DNA Origami: From Two-Dimensional to Three-Dimensional Structures.

Yan Liu1, Jin Cheng1, Sisi Fan1

  • 1Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Angewandte Chemie (International Ed. in English)
|September 7, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a new DNA origami method to transform 2D nanostructures into 3D architectures. This technique allows for controlled, resettable conversions, enabling complex programmable DNA objects for diverse applications.

Keywords:
DNA OrigamiDNA nanotechnologyDNA structuresmodular transformationnanostructures

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Area of Science:

  • Nanotechnology
  • Biomolecular Engineering
  • Materials Science

Background:

  • DNA origami is a powerful technique for nanoscale fabrication.
  • Current methods often lack efficient pathways for dynamic structural reconfiguration.
  • Creating complex, higher-order DNA nanostructures remains a challenge.

Purpose of the Study:

  • To introduce a novel strategy for reconfiguring modular DNA nanostructures.
  • To enable the transition of 2D DNA sheets into 3D architectures.
  • To develop a controlled and resettable method for DNA nanostructure transformation.

Main Methods:

  • Modularizing 2D DNA sheets into connected components.
  • Utilizing DNA "trigger" strands for independent conformational changes in modules.
  • Exploiting inter-module constraints to guide 2D to 3D structural conversion.

Main Results:

  • Demonstrated successful modularization of 2D DNA sheets into 2, 3, and 4 parts.
  • Achieved independent conformational transformation of modules using trigger strands.
  • Showcased controlled, resettable conversion of 2D sheets to 3D architectures.

Conclusions:

  • The new strategy provides an efficient route for creating programmable, higher-order DNA objects.
  • This method facilitates the construction of sophisticated dynamic substrates.
  • The approach enhances the versatility of DNA origami for advanced applications.