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Transmembrane signalling by B-lymphocyte receptors
1National Institute for Medical Research, Mill Hill, London, U.K.
The responses of B cells to specific antigens are modulated by secondary signals delivered by a variety of cell surface receptors. Besides surface immunoglobulins, these include class II MHC antigens, Fc and C3 receptors, in addition to those for various lymphokines. The current knowledge of the second messengers used by various receptors and their roles in B-cell activation are discussed here.
The responses of B cells to specific antigens are modulated by secondary signals delivered by a variety of cell surface receptors. Besides surface immunoglobulins, these include class II MHC antigens, Fc and C3 receptors, in addition to those for various lymphokines. The current knowledge of the second messengers used by various receptors and their roles in B-cell activation are discussed here.