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Pregnancy in systemic lupus erythematosus.
Aleksandra Polić1, Sarah G Običan1
1Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Birth Defects Research
|September 9, 2020
Summary
Systemic lupus erythematosus (SLE) in pregnancy presents risks like fetal loss and preterm birth. Effective management and preconception counseling are key to improving outcomes for women with SLE.
Area of Science:
- Obstetrics and Gynecology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease predominantly affecting women of reproductive age.
- Pregnancy in SLE patients requires specialized obstetric and rheumatologic care due to potential complications.
Purpose of the Study:
- To review the impact of SLE on pregnancy.
- To outline current management strategies and therapies for pregnant women with SLE.
Main Methods:
- Literature review of clinical course, diagnosis, management, and pregnancy complications in SLE patients.
Main Results:
- SLE presents variable clinical courses with flares and remissions, posing obstetric management challenges.
- Pregnancy in SLE is linked to increased risks: fetal loss, preterm birth, growth restriction, and hypertensive disorders.
- Advancements in SLE treatment have improved pregnancy outcomes, emphasizing preconception counseling and ongoing disease management.
Conclusions:
- Understanding SLE's impact on pregnancy is crucial for optimizing maternal and fetal outcomes.
- Proactive management, including preconception planning and therapy, is vital for reducing SLE-related pregnancy complications.
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