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Related Concept Videos

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Related Experiment Video

Updated: Dec 9, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Orofacial complex regional pain syndrome.

Mythili Kalladka1, Hussein Alhasan1, Nagaraju Morubagal2

  • 1Orofacial Pain and Temporomandibular Disorders, Eastman Institute for Oral Health.

Journal of Oral Science
|September 10, 2020
PubMed
Summary

Complex regional pain syndrome (CRPS) is a rare but severe facial pain disorder. This case study details orofacial CRPS diagnosis and successful treatment with a stellate ganglion block, offering hope for similar patients.

Keywords:
complex regional pain syndromeorofacial painstellate ganglion block

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Area of Science:

  • Neurology
  • Pain Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Complex regional pain syndrome (CRPS) is a debilitating neuropathic pain disorder typically affecting limbs following trauma.
  • Orofacial CRPS, a rare manifestation, presents unique diagnostic and management challenges due to the sensitive facial region.

Observation:

  • A 39-year-old female presented with chronic, severe left-sided facial pain, burning sensations, and allodynia (pain from non-painful stimuli).
  • Symptoms were exacerbated by cold exposure and stress, accompanied by visible facial swelling and redness.
  • The patient's clinical presentation aligned with the established Budapest diagnostic criteria for CRPS.

Findings:

  • Diagnostic confirmation was achieved through a stellate ganglion anesthetic block.
  • The stellate ganglion block provided significant and substantial pain relief, indicating its efficacy in managing orofacial CRPS.

Implications:

  • This case highlights the importance of considering orofacial CRPS in patients with persistent facial pain, even in the absence of typical limb involvement.
  • Successful stellate ganglion blockade suggests a viable therapeutic option for this rare and challenging condition.
  • Further research into the pathophysiology and treatment of orofacial CRPS is warranted to improve patient outcomes.