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Bisphenol A as a risk factor for allergic rhinitis in children

A Nalbantoğlu1, A Çelikkol2, N Samancı1

  • 1Department of Pediatrics, 472605Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.

Human & Experimental Toxicology
|September 10, 2020
PubMed

Insights

Children with allergic rhinitis have higher levels of Bisphenol-A (BPA), an endocrine disruptor. Increased BPA exposure is linked to more severe allergic rhinitis symptoms in children.

Area of Science:

  • Environmental Health
  • Pediatric Allergy
  • Endocrinology

Background:

  • Bisphenol-A (BPA) is an endocrine-disrupting compound with potential links to allergic diseases.
  • Limited evidence exists on the association between BPA exposure and allergic rhinitis (AR) in children.

Purpose of the Study:

  • To investigate the relationship between BPA exposure and allergic rhinitis in a pediatric population.
  • To determine if BPA levels correlate with the severity of allergic rhinitis in children.

Main Methods:

  • A case-controlled clinical study involving 140 children with AR and 140 healthy controls.
  • Measurement of serum Bisphenol-A (BPA), interleukin-4 (IL-4), interleukin-13 (IL-13), total IgE, and interferon-gamma.
  • Assessment of disease severity using total nasal symptom scores and ARIA classification.

Main Results:

  • Children with allergic rhinitis exhibited significantly higher serum levels of IL-4, IgE, and BPA compared to controls.
  • Elevated BPA and IL-4 levels were observed in children with moderate to severe persistent allergic rhinitis.
  • A positive correlation was found between total nasal symptom scores and BPA levels in children with AR.

Conclusions:

  • This study establishes a statistically significant association between BPA concentrations and allergic rhinitis in children.
  • Higher BPA levels are correlated with increased severity of allergic rhinitis in the pediatric population.
Abstract

Keywords:
Endocrine disrupting chemicalsallergicbisphenol Achildrhinitis

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