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Bisphenol A as a risk factor for allergic rhinitis in children
A Nalbantoğlu1, A Çelikkol2, N Samancı1
1Department of Pediatrics, 472605Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.
Human & Experimental Toxicology
|September 10, 2020
Summary
Children with allergic rhinitis have higher levels of Bisphenol-A (BPA), an endocrine disruptor. Increased BPA exposure is linked to more severe allergic rhinitis symptoms in children.
Area of Science:
- Environmental Health
- Pediatric Allergy
- Endocrinology
Background:
- Bisphenol-A (BPA) is an endocrine-disrupting compound with potential links to allergic diseases.
- Limited evidence exists on the association between BPA exposure and allergic rhinitis (AR) in children.
Purpose of the Study:
- To investigate the relationship between BPA exposure and allergic rhinitis in a pediatric population.
- To determine if BPA levels correlate with the severity of allergic rhinitis in children.
Main Methods:
- A case-controlled clinical study involving 140 children with AR and 140 healthy controls.
- Measurement of serum Bisphenol-A (BPA), interleukin-4 (IL-4), interleukin-13 (IL-13), total IgE, and interferon-gamma.
- Assessment of disease severity using total nasal symptom scores and ARIA classification.
Main Results:
- Children with allergic rhinitis exhibited significantly higher serum levels of IL-4, IgE, and BPA compared to controls.
- Elevated BPA and IL-4 levels were observed in children with moderate to severe persistent allergic rhinitis.
- A positive correlation was found between total nasal symptom scores and BPA levels in children with AR.
Conclusions:
- This study establishes a statistically significant association between BPA concentrations and allergic rhinitis in children.
- Higher BPA levels are correlated with increased severity of allergic rhinitis in the pediatric population.
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