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Effects of Monoacyltrehalose Fraction of Rhodococcus Biosurfactant on the Innate and Adaptive Immunity Parameters In
S V Gein1,2, O A Kochina3,4, M S Kuyukina3,4
1Institute of Ecology and Microorganic Genetics - Affiliated Branch of Perm' Federal Research Center, Ural Division of the Russian Academy of Sciences, Perm', Russia. gein@iegm.ru.
Abstract:
The biosurfactant monoacyltrehalose fraction isolated from Rhodococcus ruber IEGM 231 actinobacterium suppresses antibody production, bactericidal potential, and production of IL-1β by mouse peritoneal cells after intraperitoneal and intramuscular injection and stimulates the production of IL-10 after intraperitoneal injection. The data of in vitro experiments attest to an important role of bacterial glycolipids in the regulation of the functions of splenocytes and peritoneal macrophages.
