Related Experiment Video
Updated: Dec 9, 2025

Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
Dynamic voltage threshold adjusted substrate modification technique for complex atypical atrial flutters with varying
Nilubon Methachittiphan1,2, Nazem Akoum1, Rakesh Gopinathannair3
1Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington.
Dynamically adjusting voltage thresholds to map atrial scarring and homogenize scar tissue effectively eliminated complex atypical atrial flutter (AFL) with multiple circuits in patients post-surgery. This approach prevented tachycardia re-inducibility and long-term recurrence.
Area of Science:
- Electrophysiology
- Cardiac Surgery
- Cardiology
Background:
- Atypical atrial flutter (AFL) frequently occurs in patients with postsurgical atrial scars.
- Scar channels facilitate reentry, leading to variable flutter circuits and challenging ablation.
- Heterogeneous scarring contributes to AFL complexity and common recurrences.
Purpose of the Study:
- To test the hypothesis that dynamic voltage threshold adjustment can identify heterogeneous atrial scarring.
- To evaluate scar homogenization as a method to eliminate atypical AFLs.
- To assess the efficacy of this strategy in complex, scar-mediated AFL cases.
Main Methods:
- Studied patients undergoing atypical AFL ablation with a history of atriotomy and multiple flutter circuits.
- Excluded patients with stable, localizable flutter circuits.
- Performed high-density voltage mapping with adjusted thresholds to identify scar heterogeneity and channels.
- Utilized irrigated smart-touch ablation for scar homogenization.
- Assessed tachycardia re-inducibility and short-term/long-term outcomes.
Main Results:
- Five patients with prior surgery and multiple varying AFL morphologies were studied.
- Following scar homogenization, tachycardia was not inducible in any patient.
- No AFL recurrence was observed during a mean follow-up of 450 days.
Conclusions:
- High-density voltage mapping combined with scar homogenization is effective for complex, scar-mediated atypical AFL.
- This strategy successfully eliminates atypical AFL with multiple circuits.
- The approach offers a promising solution for challenging AFL cases post-atrial surgery.
Related Concept Videos
Dysrhythmias VI: Management of Dysrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Mechanism of Cardiac Arrhythmias
Dysrhythmias III: Characteristics of Dysrhythmias

