Related Experiment Video

Updated: Aug 19, 2026

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
10:30

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Published on: May 24, 2016

19.1K

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

HaiFang Yin, Prisca Boisguerin, Hong M Moulton

    Molecular Therapy. Nucleic Acids
    |September 13, 2020
    PubMed
    Abstract

    No abstract available in PubMed .

    More Related Videos

    Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
    05:16

    Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

    Published on: May 7, 2020

    7.2K
    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
    10:28

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

    Published on: April 3, 2021

    6.9K

    Related Experiment Videos

    Last Updated: Aug 19, 2026

    Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
    10:30

    Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

    Published on: May 24, 2016

    19.1K
    Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
    05:16

    Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

    Published on: May 7, 2020

    7.2K
    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
    10:28

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

    Published on: April 3, 2021

    6.9K

    Related Concept Videos

    Chromatin Structure Regulates pre-mRNA Processing02:41

    Chromatin Structure Regulates pre-mRNA Processing

    In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
    The chromatin structure, especially...
    Nonsense-mediated mRNA Decay02:27

    Nonsense-mediated mRNA Decay

    The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
    Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...

    Articles linked to this work by shared authors, journal, and citation graph.

    Reduced expression of human metapneumovirus matrix protein impacts virus assembly and ribonucleoprotein localization.

    Journal of virology·2026

    Timing matters: Exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy.

    Molecular therapy. Nucleic acids·2026

    Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.

    Molecular therapy. Nucleic acids·2026

    Combination of exosome vaccines, lenvatinib, and anti-PD-1 eradicates tumor in autochthonous hepatocellular carcinoma mice.

    Cell reports. Medicine·2026

    Self-Assembly of Stimuli-Responsive Peptide Enhances Therapeutics by Specifically Disrupting Hepatocellular Carcinoma Lysosomes In Vivo.

    Advanced materials (Deerfield Beach, Fla.)·2026

    Associations between the physical and social urban environment and older adults' mental health-a scoping review of reviews.

    The Gerontologist·2026

    Retraction Notice to: lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence.

    Molecular therapy. Nucleic acids·2026

    Next-generation macrophage engineering in cancer therapy: From TAM reprogramming to CAR-macrophages.

    Molecular therapy. Nucleic acids·2026

    Retraction Notice to: Long Non-coding RNA Profiling Reveals an Abundant MDNCR that Promotes Differentiation of Myoblasts by Sponging miR-133a.

    Molecular therapy. Nucleic acids·2026

    Adenovirus vector-mediated delivery of the CRISPR-CasRx system enables gene knockdown with suppressed collateral activity.

    Molecular therapy. Nucleic acids·2026

    In vivo genome editing of central nervous system SIV reservoirs in ART-suppressed rhesus macaques.

    Molecular therapy. Nucleic acids·2026

    Safety and toxicity assessment of antisense oligonucleotides in brain-relevant human cellular models.

    Molecular therapy. Nucleic acids·2026

    Host-Guest P2C9: A Wide-Band-Gap Two-Dimensional Semiconductor with Appreciable Electron Mobility.

    Journal of physics. Condensed matter : an Institute of Physics journal·2026

    Spatially programmed polymorphic crystallization via microenvironment design.

    Science advances·2026

    Tuning positive charge density in viologen-based ionic porous organic polymers for efficient electrochemical H2O2 production.

    Chemical communications (Cambridge, England)·2026

    Selenium-Functionalized Main-Chain Twisted Molecules with High Melting Points Enable Efficient and Stable Ternary Organic Solar Cells.

    ACS applied materials & interfaces·2026

    Molecular Conformation Governs Self-Assembled Monolayer Orientation for High-Performance Perovskite Photovoltaics.

    Angewandte Chemie (International ed. in English)·2026

    Tetrathiafulvalene Based Covalent Organic Frameworks Interface Layer for Antimony Chalcogenide Solar Cells.

    Small methods·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us