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Default mode network connections supporting intra-individual variability in typically developing primary school
Evgeniya Yu Privodnova1, Helena R Slobodskaya2, Andrey V Bocharov3
1Laboratory of Cognitive Physiology, Scientific Research Institute of Physiology and Basic Medicine.
Neuropsychology
|September 14, 2020
Summary
Response time variability in children is linked to brain network connectivity. Greater default mode network connectivity with certain brain regions may indicate attention lapses, impacting childhood behavioral issues.
Area of Science:
- Neuroscience
- Developmental Psychology
- Cognitive Science
Background:
- Intraindividual variability in response time (RT) offers insights into attention beyond accuracy and mean RT.
- This variability may serve as an endophenotype for clinical disorders and a marker of neurological health.
- The default mode network (DMN) and central executive and salience networks (CEN+SN) are crucial for response stability in adults.
Purpose of the Study:
- To investigate the relationship between resting-state connectivity of the DMN and CEN+SN with attention lapses in typically developing schoolchildren.
- To explore how brain network dynamics relate to response time variability in children aged 6-11 years.
Main Methods:
- Response time variability was assessed using the standard deviation of RT in a Stroop-like Animal Size Test.
- Resting-state electrophysiological signatures of the DMN and CEN+SN were captured using seed-based oscillatory power envelope correlation and beamformer spatial filtering.
- 137 typically developing children aged 6-11 years participated in the study.
Main Results:
- Positive association found between RT variability and DMN connectivity with the posterior insula and right temporal cortex (PFWE-corr < .006).
- Negative association observed between RT variability and DMN connectivity with the anterior cingulate and anterior insula (PFWE-corr = .001), areas overlapping with the SN.
- These findings were specific to the anterior DMN seed in the medial prefrontal cortex, implicated in emotion and motivation.
Conclusions:
- Default mode network connectivity patterns are associated with response time variability in children.
- These associations suggest a potential link between DMN connectivity, attention regulation, and the development of internalizing and externalizing problems in childhood.
