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Injection-site Reactions to Sustained-release Meloxicam in Sprague-Dawley Rats.

Leslie A Stewart¹, Denise M Imai², Laurel Beckett³

¹Mouse Biology Program, School of Medicine, University of California-Davis, Davis, California.

Journal of the American Association for Laboratory Animal Science : JAALAS

|September 15, 2020

Summary

This summary is machine-generated.

Extended-release meloxicam (MSR) caused significant injection-site reactions in Sprague-Dawley rats, including masses and erythema. Careful consideration of MSR use in rats is recommended due to these adverse effects.

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Area of Science:

Veterinary Medicine
Pharmacology
Animal Science

Background:

Extended-release meloxicam (MSR) is used for prolonged analgesia in rodents.
Standard meloxicam formulations are generally safe in rats, but MSR's adverse effects are poorly understood.
No prospective studies have evaluated MSR injection-site reactions in rats.

Purpose of the Study:

To characterize injection-site reactions following subcutaneous MSR administration in Sprague-Dawley rats.
To compare MSR reactions with sterile saline controls.
To evaluate the temporal progression and histopathological features of MSR-induced lesions.

Main Methods:

A single subcutaneous injection of MSR (n=16) or sterile saline (SC, n=6) was administered to Sprague-Dawley rats.
Injection sites were assessed daily for masses and erythema over 2 weeks.
Histopathology was performed on samples collected at 7 and 14 days post-injection.

Main Results:

All MSR-treated rats developed masses, with a median onset of 3 days.
Erythema appeared later, with a median onset of nearly 8 days.
Histopathology revealed localized inflammation, necrosis, and fibrosis, with some draining tracts.

Conclusions:

Subcutaneous MSR administration in Sprague-Dawley rats leads to a high prevalence and severity of injection-site reactions.
The observed lesions include masses, erythema, inflammation, necrosis, and fibrosis.
MSR use in rats warrants careful consideration due to these significant adverse effects.