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Updated: Dec 8, 2025

Quantitative Detection of Trace Explosive Vapors by Programmed Temperature Desorption Gas Chromatography-Electron Capture Detector
Published on: July 25, 2014
Detection challenges in quantitative polymer analysis by liquid chromatography
Wouter C Knol1,2, Bob W J Pirok1,2, Ron A H Peters1,2,3
1Analytical Chemistry Group, van't Hoff Institute for Molecular Sciences (HIMS), Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
Abstract:
Accurate quantification of polymer distributions is one of the main challenges in polymer analysis by liquid chromatography. The response of contemporary detectors is typically influenced by compositional features such as molecular weight, chain composition, end groups, and branching. This renders the accurate quantification of complex polymers of which there are no standards available, extremely challenging. Moreover, any (programmed) change in mobile-phase composition may further limit the applicability of detection techniques. Current methods often rely on refractive index detection, which is not accurate when dealing with complex samples as the refractive-index increment is often unknown. We review current and emerging detection methods in liquid chromatography with the aim of identifying detectors, which can be applied to the quantitative analysis of complex polymers.
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