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Autocatalytic DNAzyme assembly for amplified intracellular imaging
Keke Gong1, Qiong Wu, Hong Wang
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. fuanwang@whu.edu.cn.
Chemical Communications (Cambridge, England)
|September 17, 2020
Abstract:
The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.
