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Maternal, Perinatal and Neonatal Outcomes With COVID-19: A Multicenter Study of 242 Pregnancies and Their 248 Infant

Miguel A Marín Gabriel1,2, Mar Reyne Vergeli3, Sonia Caserío Carbonero4

  • 1Deparment of Neonatology, Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

The Pediatric Infectious Disease Journal
|September 18, 2020
PubMed

Insights

This study found no COVID-19 transmission from mothers to newborns during pregnancy or after birth. Breastfeeding rates were lower than anticipated in infants born to mothers with coronavirus disease 2019 (COVID-19).

Area of Science:

  • Perinatology
  • Infectious Diseases
  • Neonatal Care

Background:

  • Investigated clinical features of mothers with coronavirus disease 2019 (COVID-19) during pregnancy and delivery.
  • Assessed potential vertical and horizontal transmission of COVID-19 to newborns.
  • Monitored infants for one month post-discharge to evaluate transmission risks.

Purpose of the Study:

  • To describe clinical characteristics of pregnant women with COVID-19.
  • To evaluate vertical transmission of COVID-19 from mother to neonate.
  • To assess horizontal transmission of COVID-19 in newborns post-hospital discharge.

Main Methods:

  • Multicenter descriptive study across 16 Spanish hospitals.
  • Reviewed medical records of 242 pregnant women with COVID-19 in their third trimester.
  • Followed 248 newborns for one month to monitor for transmission.

Main Results:

  • Mothers hospitalized with COVID-19 had higher rates of Cesarean sections (C-sections) and increased risk of premature delivery for their newborns.
  • No cases of vertical or horizontal COVID-19 transmission were detected in the studied infants.
  • Exclusive breastfeeding rates at discharge and one month were lower than expected.

Conclusions:

  • No evidence of COVID-19 transmission during delivery or the first month of life was found in the study cohort.
  • Lower-than-expected rates of exclusive breastfeeding were observed in newborns.
  • Further research may be needed to understand breastfeeding practices in mothers with COVID-19.
Abstract

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