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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
Published on: March 21, 2018
10.2K
Advances in aptasensor technology.
Laleh Hosseinzadeh1, Mohammad Mazloum-Ardakani2
1Department of Chemistry, Dehloran Branch, Islamic Azad University, Dehloran, Iran.
Advances in Clinical Chemistry
|September 21, 2020
Summary
Aptasensors, which use aptamers for biological recognition, offer high specificity for biosensing. Recent advancements in aptamer selection and synthesis are expanding their use as biological receptors in advanced biosensor development.
Area of Science:
- Biotechnology and Biomedical Engineering
- Molecular Recognition and Biosensing
Background:
- Aptasensors are biosensors utilizing aptamers as the biological recognition element.
- Aptamers offer specificity and affinity comparable to or exceeding antibodies.
- The development of aptamers is facilitated by techniques like SELEX (Systematic Evolution of Ligands by Exponential Enrichment).
Purpose of the Study:
- To review recent developments in aptasensors for diverse targets.
- To discuss key aspects of aptasensor technology, including immobilization and design.
- To explore current limitations and future prospects of aptasensor applications.
Main Methods:
- Review of literature on aptasensor development and applications.
- Discussion of aptamer selection methodologies, particularly modified SELEX.
- Analysis of aptamer immobilization strategies and biosensor design principles.
Main Results:
- Recent advancements have enabled easier generation and synthesis of aptamers.
- Modified SELEX techniques have expanded the range of targets for aptamer isolation.
- Aptamers are increasingly applied as versatile biological receptors in biosensors.
Conclusions:
- Aptasensors represent a promising class of biosensors due to the unique properties of aptamers.
- Ongoing research in aptamer technology and biosensor design continues to address limitations.
- The future outlook for aptasensors in various applications is highly positive.
