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Serum Level of Vitamin D and Febrile Seizure? A Clinical Study

Farhad Heydarian1, Elham Bakhtiari2, Hasan Golmakani3

  • 1Research Center for Patients Safety, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Child Neurology
|September 21, 2020
PubMed

Insights

Serum vitamin D levels were normal in febrile children. While lower in those with febrile seizures, the difference was not statistically significant, suggesting further research is needed.

Area of Science:

  • Pediatrics
  • Neurology
  • Endocrinology

Background:

  • Febrile seizures are common in young children.
  • Vitamin D deficiency has been implicated in various neurological conditions.
  • The role of vitamin D in febrile seizures requires further investigation.

Purpose of the Study:

  • To compare serum vitamin D levels in children experiencing febrile seizures versus those with fever but no seizures.
  • To explore potential correlations between vitamin D status and febrile seizure occurrence.

Main Methods:

  • A cohort of 104 febrile children aged 6-60 months was studied.
  • Participants were divided into groups with and without febrile seizures.
  • Serum vitamin D levels, demographic data, and other laboratory markers were analyzed.

Main Results:

  • The mean age was higher in the febrile seizure group (26.36 ± 14.11 months) compared to the non-seizure group (16.26 ± 11.87 months).
  • Serum vitamin D levels were slightly lower in the febrile seizure group (41.92 ± 22.42 µg/dL) versus the non-seizure group (48.41 ± 15.25 µg/dL), but this difference was not statistically significant (p = 0.08).
  • Lower serum sodium, potassium, and platelet counts were observed in the febrile seizure group.

Conclusions:

  • Serum vitamin D levels were generally normal in both febrile children with and without seizures.
  • A non-significant trend of lower vitamin D levels was noted in children with febrile seizures.
  • Further clinical studies are warranted to elucidate the relationship between vitamin D and febrile seizures.
Abstract

Keywords:
ChildVitamin Dfebrile seizure

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