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Updated: Dec 8, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

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Circulating metabolomics profiling reveals novel pathways associated with cognitive decline in patients with

Yuli Huang1, Haoxiao Zheng1, Kuan Tan1

  • 1Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, China.

Therapeutic Advances in Neurological Disorders
|September 21, 2020
PubMed

Insights

Hypertension is linked to cognitive decline and Alzheimer's disease (AD) pathology. This study reveals altered blood metabolites and microbiota in hypertensive patients, offering new insights into the mechanisms of impaired cognition.

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Microbiology

Background:

  • Hypertension is a major risk factor for cardiovascular disease and dementia, including Alzheimer's disease (AD).
  • The precise mechanisms linking hypertension to AD pathology and cognitive decline remain unclear.
  • Understanding this link is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the association between hypertension, Alzheimer's disease biomarkers, and cognitive function.
  • To explore the role of metabolic and microbial alterations in hypertensive patients with cognitive impairment.

Main Methods:

  • Cognitive function assessed using Mini-Mental State Examination (MMSE).
  • Plasma amyloid-beta (Aβ)40 and Aβ42 levels measured via ELISA.
  • Metabolomics and metagenomics analyzed circulating metabolites and blood microbiota.
  • Pearson's correlation used to link cognitive scores with metabolites.

Main Results:

  • Hypertensive patients showed decreased MMSE scores and altered Aβ42/Aβ40 ratio, indicative of AD pathology.
  • Metabolomic analysis revealed enrichment in benzoate degradation and phenylpropanoid biosynthesis pathways, correlating with cognitive scores and Aβ levels.
  • Significant alterations in blood microbiota composition were observed in hypertensive individuals.

Conclusions:

  • Hypertension is associated with AD pathological biomarkers and cognitive impairment.
  • Novel metabolic and microbial pathways are implicated in hypertension-related cognitive decline.
  • These findings suggest potential therapeutic targets for managing cognitive dysfunction in hypertensive patients.
Abstract

Keywords:
Alzheimer’s diseasecirculating microbiomecognitive impairmenthypertensionmetabolomics

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