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Quantitative scintigraphy with deconvolutional analysis for the dynamic measurement of hepatic function
The Journal of Surgical Research
|June 1, 1987
Summary
Deconvolutional analysis quantitates liver function by measuring mean transit time (MTT) of 99mTc-disofenin. This method accurately assesses hepatic injury from ischemia/reperfusion, even in mild cases not visible histologically.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Hepatology
Background:
- Quantitating hepatic function scintigraphically requires accurate computational methods.
- Mean transit time (MTT) is a key parameter for assessing liver function.
- Previous methods lacked a critical computational element for precise MTT determination.
Purpose of the Study:
- To introduce and validate deconvolutional analysis for calculating hepatic MTT.
- To assess the accuracy of deconvolutional analysis in simulating tracer injection.
- To evaluate MTT as a monitor of hepatic ischemia/reperfusion injury.
Main Methods:
- Utilized deconvolutional analysis to simulate a bolus tracer injection into the liver.
- Administered intravenous 99mTc-disofenin (a HIDA analog) for data acquisition.
- Correlated MTT results with Bromosulfophthalein (BSP) tests and hepatic histology under induced ischemia/reperfusion.
Main Results:
- Deconvolutional analysis accurately simulates tracer injection dynamics.
- Prolonged MTT correlated with severe hepatic histologic damage (necrosis, vacuolization).
- Quantitative imaging and BSP testing detected milder hepatic injuries missed by histology.
Conclusions:
- Deconvolutional analysis provides a sensitive and accurate method for hepatic function assessment.
- The technique is adaptable to standard nuclear medicine equipment.
- MTT measurement via deconvolution is a valuable tool for monitoring hepatic ischemia/reperfusion injury.