Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
Types of RNA01:20

Types of RNA

8.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.5K
Types of RNA01:23

Types of RNA

71.7K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
71.7K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.3K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.3K
Translational Regulation01:29

Translational Regulation

415
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
415

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic degradation of circular RNAs by RNAseK and lysosome.

Cell reports·2026
Same author

A conserved mammalian mecciRNA, mecciATP6, regulates mitochondrial homeostasis through interaction with HNRNPA3.

Non-coding RNA research·2026
Same author

Bladder cancer organoids: bridging pathological features and drug response for precision oncology.

International urology and nephrology·2026
Same author

Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

New insights into mitochondria-encoded circular RNAs and their functions.

Trends in biochemical sciences·2026
Same author

Repeated <i>Aedes albopictus</i> bites reshape gut microbiota and repattern inflammatory readouts in a murine colitis model.

Frontiers in microbiology·2025
Same journal

Identification of long non-coding RNAs involved in leukemogenesis and venetoclax response in acute myeloid leukemia through functional CRISPR-dCas9 interference screens.

Non-coding RNA research·2026
Same journal

LncRNA MIR22HG and miR-10a-5p: Pioneering serum biomarkers for pancreatic cancer diagnosis and progression assessment.

Non-coding RNA research·2026
Same journal

CRISPR decodes the RNA regulatory network in prostate cancer: A review from mechanisms to precision therapeutics.

Non-coding RNA research·2026
Same journal

tRNA-derived small RNAs in ocular neovascular diseases: A systematic review.

Non-coding RNA research·2026
Same journal

Discovery of a G-rich ultra stable human ncRNA G-quadruplex that binds ATP.

Non-coding RNA research·2026
Same journal

Functional role of long non-coding RNA MALAT1 and HOTAIR in lung cancer.

Non-coding RNA research·2026
See all related articles

Related Experiment Video

Updated: Dec 8, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K

The physiological function of long-noncoding RNAs.

He Chen1, Ge Shan1

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui Province, 230027, China.

Non-Coding RNA Research
|September 22, 2020
PubMed
Summary
This summary is machine-generated.

Long-noncoding RNAs (lncRNAs) regulate physiological processes in animals. This review focuses on lncRNA functions and mechanisms at the organismal level, using animal models like worms and flies.

Keywords:
CRISPRCircRNALincRNALong noncoding RNAPhenotypePhysiological function

More Related Videos

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.2K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.2K

Related Experiment Videos

Last Updated: Dec 8, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K
Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.2K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.2K

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Biological macromolecules, including long-noncoding RNAs (lncRNAs), are crucial for regulating physiological processes in cells and organisms.
  • lncRNAs are non-protein-coding RNA molecules distinguished from small-noncoding RNAs by their length.
  • lncRNAs exert cis or trans effects, influencing diverse life events such as development, metabolism, and aging in animals.

Purpose of the Study:

  • To investigate the physiological functions of lncRNAs within cells.
  • To focus on the functions and underlying mechanisms of lncRNAs at the organismal level.
  • To summarize and discuss studies on lncRNAs utilizing classic animal models.

Main Methods:

  • Review of existing literature on lncRNA functions in cellular and organismal contexts.
  • Analysis of studies employing animal models, specifically worms and flies, to elucidate lncRNA roles.
  • Comparative analysis of lncRNA functions at cellular versus organismal levels.

Main Results:

  • Evidence suggests lncRNAs play distinct roles at both cellular and organismal levels.
  • Many annotated lncRNAs may represent transcriptional noise rather than essential functional elements.
  • lncRNAs are implicated in a wide array of physiological processes and life events in animals.

Conclusions:

  • lncRNAs are critical regulators of animal physiology, with significant roles extending from the cellular to the organismal scale.
  • Understanding lncRNA mechanisms in model organisms provides insights into their broader physiological importance.
  • Further research is needed to distinguish functional lncRNAs from transcriptional noise and fully elucidate their complex roles.