Related Experiment Video
Updated: Dec 8, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
A substituent-induced post-assembly modification cascade of a metallosupramolecular imine-type Co-complex
Grzegorz Markiewicz1, Bartosz Orwat1, Miłosz Piechocki1
1Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. irekk@o365.amu.edu.pl ars@amu.edu.pl and Center for Advanced Technologies, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland.
Abstract:
Here, we report a reaction cascade employing the substituent-induced post-assembly modification of a Co(iii) complex. Unexpectedly, we found that the (triisopropylsilyl)alkynyl moiety introduced to the Sonogashira reaction with the bromo-functionalized Co(iii) assembly plays a "Trojan horse" role, triggering a subsequent, second step of the cascade, i.e. Co(iii) to Co(ii) reduction. The reported substituent-activated Sonogashira-redox cascade reaction might set a new direction in the construction of specific chemical sensors.
Related Concept Videos
Aldehydes and Ketones with Amines: Imine Formation Mechanism
Imines are formed under mildly acidic conditions. A pH of 4.5 is ideal for the reaction.
If the pH is low or the solution is too acidic, the reaction slows down in the...
Aldehydes and Ketones with Amines: Imine and Enamine Formation Overview
Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Directing Effect of Substituents: meta-Directing Groups
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

