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Image-Guided Intensity-Modulated Radiation Therapy for IgG4-Related Ophthalmic Disease
Rachel A Sabol1, Virginia Bubenzer2, Krzysztof Moroz3
1Tulane University School of Medicine, New Orleans, LA, USA.
Case Reports in Ophthalmological Medicine
|September 23, 2020
Summary
Radiotherapy offers a promising treatment for IgG4-related ophthalmic disease (IgG4-OFD) when corticosteroids fail. This approach successfully resolved symptoms in a patient with refractory IgG4-OFD.
Area of Science:
- Ophthalmology
- Immunology
- Radiation Oncology
Background:
- IgG4-related ophthalmic disease (IgG4-OFD) is a rare condition.
- First-line corticosteroid therapy has high failure rates.
- Limited alternative management options exist for IgG4-OFD.
Observation:
- A patient presented with recurrent orbital inflammation and lacrimal gland involvement.
- Initial treatments including dacryoadenectomy and corticosteroids were ineffective.
- Diagnosis was confirmed by biopsy and florid IgG4 staining.
Findings:
- Image-guided intensity-modulated radiotherapy (IG-IMRT) to the orbit was administered.
- The patient received 20 Gy in 10 fractions.
- Ophthalmic symptoms completely resolved following radiotherapy.
Implications:
- Radiotherapy may be a viable treatment for refractory IgG4-OFD.
- This case suggests a favorable response to radiotherapy in select patients.
- Further research into radiotherapy for IgG4-OFD is warranted.
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