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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Neuroretinitis Secondary to Toxoplasma Infection in an Adult
Shamila Ladak1, M A Rehman Siddiqui2
1Medical College, Aga Khan University Hospital, Karachi, Pakistan, aku.edu.
Case Reports in Ophthalmological Medicine
|July 30, 2026
Summary
A healthy adult developed neuroretinitis due to active Toxoplasma infection. Prompt treatment with trimethoprim-sulfamethoxazole led to vision recovery, highlighting toxoplasmosis as a key differential diagnosis for neuroretinitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Immunology
Background:
- Neuroretinitis is an ocular inflammatory condition affecting the optic nerve and retina.
- Toxoplasmosis, a parasitic infection, can manifest in various ways, including ocular involvement.
Purpose of the Study:
- To report a case of neuroretinitis in a healthy adult with active primary Toxoplasma infection.
- To emphasize the importance of considering toxoplasmosis in the differential diagnosis of neuroretinitis.
Main Methods:
- Case report of a 27-year-old woman with sudden vision loss.
- Ophthalmic examination including Optical Coherence Tomography (OCT).
- Laboratory workup for infectious agents, including Toxoplasma gondii antibody testing.
Main Results:
- The patient presented with blurred vision, central scotoma, optic disc edema, and macular star formation.
- OCT revealed optic disc elevation and retinal nerve fiber layer thickening.
- Positive IgM and IgG antibodies for Toxoplasma gondii confirmed active infection. Treatment resulted in significant resolution of ocular findings.
Conclusions:
- Toxoplasmosis should be considered in the differential diagnosis of neuroretinitis, even in immunocompetent individuals.
- Early diagnosis and treatment of ocular toxoplasmosis are crucial for preventing permanent vision loss.
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