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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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TG6 Auto-Antibodies in Dermatitis Herpetiformis
Marios Hadjivassiliou1, Timo Reunala2,3, Kaisa Hervonen2,3
1Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Sheffield S10 2JF, UK.
Nutrients
|September 24, 2020
Summary
Dermatitis herpetiformis (DH) is linked to gluten sensitivity and antibodies against transglutaminases. This study found TG6 antibodies are more prevalent in DH patients than celiac disease patients, suggesting a role in gluten-related disorders.
Area of Science:
- Immunology
- Gastroenterology
- Dermatology
Background:
- Dermatitis herpetiformis (DH) is an autoimmune manifestation of gluten sensitivity, with antibodies targeting epidermal transglutaminase 3 (TG3).
- Celiac disease (CD) involves antibodies against TG2, while neurological gluten sensitivity involves TG6.
- The interplay and diagnostic value of antibodies against TG2, TG3, and TG6 across gluten-related disorders (GRD) are not fully understood.
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