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Necrobiotic Xanthogranuloma on 18F-FDG PET/CT
Mohamed Eltilib1, Jordan Fenner, Israel Saramago
1From the University of North Carolina School of Medicine.
This case study details necrobiotic xanthogranuloma, a rare histiocytosis presenting as chronic skin lesions. F-FDG PET/CT aids in staging and monitoring this condition.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Necrobiotic xanthogranuloma (NXG) is a rare non-Langerhans histiocytosis.
- NXG is characterized by chronic cutaneous nodules that evolve into plaques.
Observation:
- A 57-year-old man presented with a 6-year history of yellowish plaques and ulcerating subcutaneous nodules.
- Lesions were located on the buttock, knee, and forearms.
Findings:
- Skin and bone biopsies confirmed NXG.
- Serum protein electrophoresis revealed associated monoclonal gammopathy.
- Diagnosis: Necrobiotic xanthogranuloma with monoclonal gammopathy.
Implications:
- Discusses NXG presentation and clinical course.
- Highlights the utility of F-FDG PET/CT for disease staging.
- Explores F-FDG PET/CT in guiding biopsy site selection and assessing treatment response.
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