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An Energy-Efficient Optically-Enhanced Highly-Linear Implantable Wirelessly-Powered Bidirectional Optogenetic

Tayebeh Yousefi, Mansour Taghadosi, Alireza Dabbaghian

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    |September 25, 2020
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    This summary is machine-generated.

    This study introduces an energy-efficient, mm-scale neuro-stimulator for optogenetics. It features a novel LED driver and printed lenses, enhancing stimulation efficiency and enabling bidirectional neural recording.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Optogenetics

    Background:

    • Optogenetic neurostimulation requires efficient, miniaturized devices for precise neural control.
    • Existing systems often face limitations in energy efficiency, size, and integration of recording capabilities.

    Purpose of the Study:

    • To develop a compact, energy-efficient, bidirectional optogenetic neuro-stimulator.
    • To enhance light delivery and control for targeted neural stimulation.
    • To integrate neural recording functionalities within the same device.

    Main Methods:

    • Designed a highly-linear, current-mode micro-LED driver circuit for precise stimulation control.
    • Utilized inkjet-printed, custom-designed optical micro-lenses to improve light directivity.
    • Integrated Local Field Potential (LFP) recording channels and power management blocks onto a System-on-Chip (SoC).
    • Embedded a micro-coil for inductive wireless power transfer.

    Main Results:

    • Achieved linear control of optical stimulation up to 10 mA with minimal headroom, boosting energy conversion efficiency.
    • Demonstrated a 30.46x improvement in power delivery efficiency to target tissue using printed micro-lenses.
    • Reported a 2.24% Power Transfer Efficiency (PTE) for the wireless power link.
    • Fabricated a self-contained system (6 mm³, 12.5 mg) with integrated μLEDs, μlenses, and recording channels.

    Conclusions:

    • The developed mm-scale neuro-stimulator offers significant advancements in energy efficiency and miniaturization for optogenetic applications.
    • The combination of a novel LED driver and printed optics enhances stimulation performance.
    • Integrated bidirectional capabilities (stimulation and recording) in a compact form factor open new possibilities for neuroscience research.