Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular determinants of low affinity complexes formed by the electrical synapse proteins Connexin 36 and ZO-1.

bioRxiv : the preprint server for biology·2025
Same author

Closed-Loop Implantable Neurostimulators for Individualized Treatment of Intractable Epilepsy: A Review of Recent Developments, Ongoing Challenges, and Future Opportunities.

IEEE transactions on biomedical circuits and systems·2025
Same author

Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein.

The Journal of biological chemistry·2023
Same author

A 0.67 μV-IIRN super-T Ω-Z <sub>IN</sub> 17.5 μW/Ch Active Electrode With In-Channel Boosted CMRR for Distributed EEG Monitoring.

IEEE transactions on biomedical circuits and systems·2023
Same author

An 8-Channel Ambulatory EEG Recording IC With In-Channel Fully-Analog Real-Time Motion Artifact Extraction and Removal.

IEEE transactions on biomedical circuits and systems·2023
Same author

A 21.3%-Efficiency Clipped-Sinusoid UWB Impulse Radio Transmitter With Simultaneous Inductive Powering and Data Receiving.

IEEE transactions on biomedical circuits and systems·2022

Related Experiment Video

Updated: May 24, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.6K

A Highly-Scalable Poisson-Coded Retinal Optogenetic Stimulator With Fully-Analog ED-Based Adaptive Spike Detection

Tayebeh Yousefi, Georg Zoidl, Hossein Kassiri

    IEEE Transactions on Biomedical Circuits and Systems
    |March 3, 2025
    PubMed
    Summary
    This summary is machine-generated.

    We developed a scalable, inductively powered optogenetic stimulator for prosthetic vision. This system enhances stimulation efficacy and visual perception quality through adaptive, closed-loop control and efficient design.

    More Related Videos

    In vivo Optogenetic Stimulation of the Rodent Central Nervous System
    09:37

    In vivo Optogenetic Stimulation of the Rodent Central Nervous System

    Published on: January 15, 2015

    59.1K
    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
    13:44

    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

    Published on: September 2, 2013

    19.0K

    Related Experiment Videos

    Last Updated: May 24, 2025

    Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
    06:36

    Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

    Published on: September 1, 2022

    3.6K
    In vivo Optogenetic Stimulation of the Rodent Central Nervous System
    09:37

    In vivo Optogenetic Stimulation of the Rodent Central Nervous System

    Published on: January 15, 2015

    59.1K
    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
    13:44

    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

    Published on: September 2, 2013

    19.0K

    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Optogenetics

    Background:

    • Optogenetic stimulation is a promising tool for neural prosthetics, but challenges remain in achieving high channel counts, energy efficiency, and precise control.
    • Current systems often struggle with scalability and adapting to individual patient variations.

    Purpose of the Study:

    • To present a fully implantable, inductively powered optogenetic stimulator designed for enhanced prosthetic vision.
    • To improve stimulation efficacy, pathway specificity, energy efficiency, and channel-count scalability.
    • To develop a closed-loop system for adaptive light intensity control based on neural feedback.

    Main Methods:

    • Leveraged opsin photon integration properties with raster scanning and Poisson-coded stimulation for uniform power and reduced wiring.
    • Implemented a compact, power-efficient, SNR-boosted, ADC-less spike detection circuit for real-time feedback.
    • Fabricated a 3x3 mm IC in 180nm CMOS coupled with a 100-channel custom optrode array using InGaN on sapphire.

    Main Results:

    • Demonstrated a scalable system supporting more stimulation channels without compromising safety or functionality.
    • Achieved adaptive control of LED light intensity based on retinal ganglion cell (RGC) spiking activity.
    • Validated circuit-level performance, system-level efficacy, and in-vitro performance, showing advantages over existing systems.

    Conclusions:

    • The developed optogenetic stimulator offers significant improvements for prosthetic vision applications.
    • Closed-loop adaptivity ensures consistent and effective stimulation, enhancing visual perception quality and energy efficiency.
    • The system's scalability and efficiency represent a substantial advancement in implantable neural stimulation technology.