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Updated: Dec 7, 2025

X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
Published on: July 18, 2019
Generation and Characterization of Mouse Models for Skeletal Disease
Gabrielle E Foxa1, Ye Liu1, Lisa M Turner2
1Program for Skeletal Disease and Tumor Microenvironment, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.
Abstract:
Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that induce symptoms modeling OA. Here, we will describe protocols outlining the induction of experimental OA in mice as well as detailed descriptions of methods for analyzing skeletal phenotypes using micro-computerized tomography and skeletal histomorphometry.
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