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Updated: Dec 7, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Antiphospholipid Antibody and Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis
1Department of Neurology (Y.K.), Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Background And Purpose:
Although aPLs (antiphospholipid antibodies) are associated with thrombotic events, especially in young patients, the role of aPLs in recurrent ischemic strokes (RIS) is unclear. This systematic review and meta-analysis evaluated the association between aPLs and RIS.
Methods:
The systematic review was conducted by a computer-assisted search of literature in PubMed, EMBASE, and Cochrane library published in English or Korean from 1990, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA). Review Manager 5.3 software was used for statistical analyses.
Results:
Of the 2272 identified articles, 8 studies were included (2510 subjects; 844 aPL positive). The meta-analysis revealed a relative risk of aPLs for RIS of 1.41 (95% CI, 0.91-2.17; I2=54%). In the subgroup analysis, age <50 years, ethnicity, and type of aPL did not increase the risk of RIS.
Conclusions:
We found that aPLs are not an independent predictor for RIS in adults. However, considering the nonstandardized disease criteria, further well-designed prospective trials should be considered to confirm these findings.
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