Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients
I M Madaeva1, N A Kurashova2, N V Semenova2
1Research Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. nightchild@mail.ru.
Abstract:
We studied the level of heat shock protein HSP70 under conditions of oxidative stress in 47 patients with apnea. The control group included 13 healthy subjects without verified apnea. Blood serum, plasma, and erythrocyte hemolysate were used to determine LPO and anti-oxidant protection components by spectrophotometrical and spectrofluorometrical methods. HSP70 was assayed by ELISA. A direct relationship was established between the intensity of oxidative stress and HSP70 expression in patients with apnea. Quantitative determination of HSP70 can be used as a molecular marker in the early diagnosis and prognosis of the development of various pathological conditions in hypoxia.
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