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SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review
Inderbir Singh1, Ajay Kumar Thakur1, Rajni Bala1
1Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Current Drug Research Reviews
|September 29, 2020
Summary
The SeDeM (Sediment Delivery Model) expert system aids in selecting excipients for direct compression tablet manufacturing. SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) further refines this process, reducing drug development time.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- The SeDeM (Sediment Delivery Model) expert system is a preformulation tool for assessing direct compression suitability of pharmaceutical excipients.
- SeDeM utilizes a 12-parameter diagram, while SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) employs a 15-parameter diagram to aid research and reduce product development timelines.
- These systems facilitate the screening of optimal excipients for specific active pharmaceutical ingredients in direct compression.
Purpose of the Study:
- To review the development and applications of the SeDeM and SeDeM-ODT expert systems.
- To highlight the utility of these systems in pharmaceutical preformulation and formulation development.
Main Methods:
- Review of existing literature and case studies on SeDeM and SeDeM-ODT applications.
- Analysis of the parameters and diagrams used in both SeDeM and SeDeM-ODT systems.
Main Results:
- SeDeM and SeDeM-ODT systems have been successfully applied in characterizing excipient properties.
- These systems are effective in evaluating direct compression suitability and guiding the development of various tablet formulations, including ODTs and sustained-release tablets.
- The application extends to the development of tablets with taste-masked drugs.
Conclusions:
- The SeDeM and SeDeM-ODT systems are valuable tools in pharmaceutical research and development.
- Detailed discussion on the development and diverse applications of these expert systems is provided in this review.
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