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Related Concept Videos

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The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
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Distributed processing of side-choice biases.

Mario Treviño1, Ricardo Medina-Coss Y León1

  • 1Laboratorio de Plasticidad Cortical y Aprendizaje Perceptual, Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.

Brain Research
|October 1, 2020
PubMed
Summary
This summary is machine-generated.

Mice exhibit choice biases in perceptual tasks. Researchers found that inactivating specific brain circuits, like the visual cortex or substantia nigra, altered these biases, revealing internal circuit contributions to decision-making variability.

Keywords:
Choice-biasDistributed processingMousePharmacological inactivationPosterior Parietal CortexVisual cortex

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Area of Science:

  • Neuroscience
  • Perception
  • Decision Making

Background:

  • Psychophysics links stimulus strength to perceptual performance.
  • Non-sensory factors in perceptual decision-making remain unclear.
  • Choice biases in two-alternative forced-choice tasks are prevalent and stimulus-independent in mice.

Purpose of the Study:

  • Investigate the neural circuits underlying choice biases in adult mice.
  • Determine how different brain regions contribute to side-choice behavior.

Main Methods:

  • Inactivation of specific brain regions in adult mice.
  • Observation of changes in biased choice behavior.
  • Analysis of the impact of contralateral and ipsilateral inactivations.

Main Results:

  • Contralateral inactivation of visual and parietal cortices reduced preferred-side choices.
  • Ipsilateral inactivation of substantia nigra pars reticulata reduced preferred-side choices.
  • Ipsilateral inactivation of frontal orienting fields increased preferred-side choices.

Conclusions:

  • Internal circuit processing significantly contributes to side-choice behavior.
  • Distinct brain regions play specific roles in generating choice biases.
  • Understanding these circuits can illuminate normal and aberrant choice variability.