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Hydrolysed wheat based oral rehydration solution for acute diarrhoea.
Archives of Disease in Childhood
|May 1, 1987
Summary
This study found that oral rehydration solutions (ORS) made from wheat or rice were less effective than glucose-based ORS for children with acute diarrhea, showing reduced intake and stool output. Further research is needed to optimize these alternative rehydration therapies.
Area of Science:
- Pediatrics
- Gastroenterology
- Public Health
Background:
- Acute diarrhea remains a significant health concern in children globally.
- Oral rehydration solution (ORS) is a cornerstone of diarrhea management.
- Exploring alternative ORS formulations is crucial for improving accessibility and efficacy.
Purpose of the Study:
- To compare the efficacy of oral rehydration solutions (ORS) derived from partially hydrolyzed wheat grain and cooked rice powder against a glucose-based ORS.
- To evaluate the impact of these ORS formulations on fluid intake and stool output in children with acute diarrhea.
Main Methods:
- A randomized controlled trial involving 78 children with acute diarrhea.
- Three groups received ORS formulated with wheat, rice, or glucose.
- Initial intravenous rehydration was followed by ORS administration.
Main Results:
- Children receiving wheat-ORS and rice-ORS demonstrated significantly lower ORS intake compared to the glucose-ORS group during the first 48 hours.
- Stool output was also significantly reduced in the wheat-ORS and rice-ORS groups relative to the glucose-ORS group.
- These trends were consistent across the observation periods.
Conclusions:
- Partially hydrolyzed wheat grain and cooked rice powder based ORS formulations showed reduced efficacy compared to glucose-based ORS in managing acute diarrhea in children.
- Further investigation into optimizing the composition and delivery of alternative ORS is warranted.