Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.3K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.3K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.5K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.5K
The Central Dogma01:20

The Central Dogma

31.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
31.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells.

Science advances·2026
Same author

Collagen hydrogel tube microbioreactors for cell and tissue manufacturing.

Biofabrication·2025
Same author

Development of a whole cell vaccine to activate dendritic cells using polyvalent CpG.

Materials horizons·2025
Same author

DNA-Scaffolded Bispecific Antibodies Enhance Mesenchymal Stromal Cell Therapy for Inflammatory Bowel Disease.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Single-cell encapsulation of mesenchymal stromal cells <i>via</i> ECM-mimetic supramolecular hydrogels enhances therapeutic efficacy.

Biomaterials science·2025
Same author

DNA-Guided Multivalent Antibody Display Boosts the Targeting Performance of Therapeutic Nanovesicles.

ACS applied materials & interfaces·2025
Same journal

Efficient Syngas Photoproduction Enabled by Electronic Engineering of Co-Immobilized Imine COFs.

Angewandte Chemie (International ed. in English)·2026
Same journal

Pathway Controlled Phase Separation of Minimal Building Blocks Utilizing a Dissociative Chemical Transformation.

Angewandte Chemie (International ed. in English)·2026
Same journal

Interaction Hierarchy and Polymorphic Structure-Property Dynamics in Luminescent Molecular Crystals.

Angewandte Chemie (International ed. in English)·2026
Same journal

The Role of Zn-Hf Site Proximity and Oxygen Vacancies for Methanol Formation Over ZnHfO<sub>x</sub> Catalysts Under CO<sub>2</sub> Hydrogenation Conditions.

Angewandte Chemie (International ed. in English)·2026
Same journal

Breaking the Linear Scaling Relationship: Bioinspired Electronic Coupling in S-Bridged Fe-Fe Dual Sites for Efficient Oxygen Reduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.4K

Synthetic DNA for Cell-Surface Engineering.

Peng Shi1, Yong Wang1

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Angewandte Chemie (International Ed. in English)
|October 2, 2020
PubMed
Summary
This summary is machine-generated.

Synthetic DNA and DNA nanostructures can engineer cell surfaces, enhancing cell-environment communication for applications like cell recognition and sensing. This technology offers advanced cellular functions beyond natural evolution.

Keywords:
DNAcell-surface engineeringmolecular recognitionself-assemblysupramolecular structures

More Related Videos

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

7.8K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.2K

Related Experiment Videos

Last Updated: Dec 7, 2025

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.4K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

7.8K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.2K

Area of Science:

  • Biotechnology
  • Synthetic Biology
  • Cell Biology

Background:

  • The cell membrane is a critical regulator of cell-environment communication.
  • Functionalizing cell membranes with synthetic components can expand cellular capabilities.
  • Synthetic DNA offers a versatile platform for cell-surface engineering.

Purpose of the Study:

  • To review recent advancements in using synthetic DNA and DNA nanostructures for cell-surface engineering.
  • To introduce methods for monovalent and polyvalent surface modification.
  • To highlight applications of DNA-based cell engineering.

Main Methods:

  • Chemical conjugation for attaching synthetic molecules to cell surfaces.
  • Physical binding techniques for surface modification.
  • Development of DNA-based nanostructures for cell functionalization.

Main Results:

  • Demonstrated methods for both monovalent and polyvalent cell-surface engineering using DNA.
  • Showcased applications in promoting cell-cell recognition and regulating intracellular pathways.
  • Highlighted use in protecting therapeutic cells and sensing microenvironments.

Conclusions:

  • Synthetic DNA and DNA nanostructures represent powerful tools for advanced cell-surface engineering.
  • These engineered systems can modulate cell-environment interactions for diverse applications.
  • Addressing current challenges will further unlock the potential of DNA-based cellular technologies.