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Related Experiment Video

Updated: Dec 6, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Human Embryogenesis: A Comparative Perspective.

Claudia Gerri¹, Sergio Menchero², Shantha K Mahadevaiah²

¹Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom;

Annual Review of Cell and Developmental Biology

|October 6, 2020

Summary

This summary is machine-generated.

Direct study of human embryos, aided by new genetic tools, reveals conserved and divergent early development mechanisms across mammals. This comparative embryology approach deepens understanding and impacts regenerative medicine.

Keywords:

comparative embryology human embryogenesis mammalian development placenta pluripotency stem cell models

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Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

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Published on: June 12, 2020

Area of Science:

Developmental Biology
Evolutionary Biology
Genetics

Background:

Historically, human embryology research depended on mammalian models.
Recent technological advancements enable direct study of human embryos, including genetic and epigenetic analyses.
This shift allows for a broader understanding of early embryogenesis.

Purpose of the Study:

To provide an overview of human preimplantation development.
To contextualize human development within mammalian evolution through comparative analysis.
To discuss advances in postimplantation development studies and relevant stem cell models.

Main Methods:

Comparative analysis of preimplantation development across eutherian and metatherian species.
Review of advancements in studying postimplantation development.
Discussion of stem cell models mimicking postimplantation embryos.

Main Results:

Direct study of human embryos offers new insights into early development.
Comparative embryology highlights conserved and divergent mechanisms in mammalian evolution.
Stem cell models provide valuable tools for studying postimplantation development.

Conclusions:

A comparative approach, integrating molecular and functional studies across species, is crucial for understanding early development principles.
Direct human embryo research and comparative embryology have significant implications for regenerative medicine.
This field also raises important ethical considerations.