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Related Experiment Video

Updated: Dec 6, 2025

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

Recent developments in MOG-IgG associated neurological disorders.

Harald Hegen¹, Markus Reindl²

¹Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Therapeutic Advances in Neurological Disorders

|October 8, 2020

Summary

Myelin oligodendrocyte glycoprotein IgG antibody (MOG-IgG) disorders are a distinct inflammatory CNS disease. These MOG-IgG conditions present a wide spectrum of neurological syndromes in children and adults.

Keywords:

acute disseminated encephalomyelitis antibody encephalitis myelin oligodendrocyte glycoprotein optic neuritis seizure transerve myelitis

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Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

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Last Updated: Dec 6, 2025

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

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Published on: August 16, 2024

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice

Published on: April 15, 2014

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

Area of Science:

Neuroimmunology
Neurology

Background:

Acquired demyelinating syndromes associated with myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG) are increasingly recognized as a distinct inflammatory central nervous system disease entity.
These disorders are differentiated from neuromyelitis optica spectrum disorders and multiple sclerosis.

Purpose of the Study:

To provide a comprehensive overview of current knowledge regarding MOG-IgG associated disorders.
To describe clinical presentations, differentiate from other demyelinating diseases, and summarize outcomes and treatments.

Main Methods:

Utilizing highly specific cell-based assays for MOG-IgG detection.
Reviewing meticulous clinical descriptions and recent studies on MOG-IgG associated disorders.

Main Results:

MOG-IgG associated disorders encompass a spectrum from acute disseminated encephalomyelitis in children to optic neuritis and myelitis in adults.
The phenotype has expanded to include brainstem encephalitis, seizures, and overlap syndromes with other autoimmune encephalitides.

Conclusions:

MOG-IgG associated disorders represent a unique category of inflammatory CNS diseases with diverse clinical manifestations.
Understanding MOG-IgG pathophysiology and diagnostic methods is crucial for accurate diagnosis and management.