Jove
Visualize
Contact Us

Related Concept Videos

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

3.6K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
3.6K
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

3.1K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
3.1K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

4.1K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
4.1K
Organization of the Brain01:30

Organization of the Brain

1.9K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
1.9K
The Spinal Cord01:54

The Spinal Cord

30.9K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
30.9K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

3.6K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mouse dorsal raphe nucleus as understood by temporal Fgf8 lineage analysis.

The Journal of comparative neurology·2020
Same author

A 5-HT<sub>1D</sub> -receptor agonist protects Dravet syndrome mice from seizure and early death.

The European journal of neuroscience·2020
Same author

Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT<sub>3</sub> receptor binding in the NTS in anesthetized rat pups.

Experimental neurology·2019
Same author

Serotonin abnormalities in Dravet syndrome mice before and after the age of seizure onset.

Brain research·2019
Same author

Embracing diversity in the 5-HT neuronal system.

Nature reviews. Neuroscience·2019
Same author

Delayed Antidepressant Efficacy and the Desensitization Hypothesis.

ACS chemical neuroscience·2019
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 6, 2025

Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique
09:54

Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique

Published on: February 26, 2016

10.8K

Dorsal raphe organization.

Kathryn G Commons1

  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Department of Anæsthesia, Harvard Medical School, 300 Longwood Ave., Enders 311, Boston, MA, 02115, United States.

Journal of Chemical Neuroanatomy
|October 8, 2020
PubMed
Summary
This summary is machine-generated.

Recent studies reveal complex transcriptional diversity in serotonin neurons of the dorsal raphe nucleus (DR). These findings suggest new relationships between DR neuron subtypes and highlight the need for integrated organizational schemes.

Keywords:
Cell typesDorsal rapheMedian rapheMetVglut3

More Related Videos

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
10:13

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

20.2K
Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes
08:25

Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes

Published on: January 12, 2020

6.5K

Related Experiment Videos

Last Updated: Dec 6, 2025

Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique
09:54

Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique

Published on: February 26, 2016

10.8K
Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
10:13

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

20.2K
Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes
08:25

Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes

Published on: January 12, 2020

6.5K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The dorsal raphe nucleus (DR) is a key source of serotonin in the brain.
  • Understanding the heterogeneity of serotonin neurons within the DR is crucial for deciphering brain function.
  • Recent advancements have provided new insights into the transcriptional landscape of DR serotonin neurons.

Purpose of the Study:

  • To highlight implications of recent studies on DR serotonin neuron transcriptional diversity.
  • To propose a more integrated approach for understanding DR organization.
  • To synthesize existing and new information on serotonin neuron diversity.

Main Methods:

  • Review and synthesis of recent research findings.
  • Analysis of transcriptional data from serotonin neurons.
  • Correlation of transcriptional profiles with known neuronal features.

Main Results:

  • Serotonin neurons in the lateral wings of the DR show a close relationship with rostral and dorsal subtypes.
  • Cre-lines used in research may not exclusively target single transcriptional subtypes but can span multiple.
  • New organizational schemes for DR neurons are being developed.

Conclusions:

  • The transcriptional diversity of DR serotonin neurons is more complex than previously thought.
  • Future research should integrate transcriptional data with other neuronal characteristics for a comprehensive understanding of DR organization.
  • Developing refined organizational schemes is essential for advancing neuroscience research.