Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

1.2K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Significance and Immune Landscape of Neuroendocrine Differentiation-Related Genes in Non-Small Cell Lung Cancer.

Biological procedures online·2026
Same author

A Review and Perspective of Techniques for Autonomous Robotic Ultrasound Acquisitions.

Sensors (Basel, Switzerland)·2026
Same author

Genetic deletion of miR-200a/200b increases growth and feed conversion efficiency in yellow catfish.

Science China. Life sciences·2026
Same author

Wearable sensors for monitoring drug pharmacokinetics in patients with Parkinson's disease.

Scientific reports·2026
Same author

CRISPR-associated transposon for programmable viral vector engineering and prime editing.

Nucleic acids research·2026
Same author

Buc Maintains Maternal RNA Stability and Embryogenesis in Zebrafish.

Cells·2025

Related Experiment Video

Updated: Dec 6, 2025

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

6.6K

A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement.

Siang-Sin Shan, Shao-Yung Lu, Yuan-Po Yang

    IEEE Transactions on Biomedical Circuits and Systems
    |October 9, 2020
    PubMed
    Summary

    This study introduces a novel pulse-stimulus sensor readout circuit for detecting Cardiac Troponin I, a key biomarker for cardiovascular disease. The developed system offers high sensitivity and a wide dynamic range for improved diagnostic capabilities.

    More Related Videos

    Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
    08:33

    Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

    Published on: July 18, 2025

    640
    A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
    10:12

    A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

    Published on: August 8, 2013

    17.0K

    Related Experiment Videos

    Last Updated: Dec 6, 2025

    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
    09:23

    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

    Published on: December 13, 2017

    6.6K
    Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
    08:33

    Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

    Published on: July 18, 2025

    640
    A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
    10:12

    A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

    Published on: August 8, 2013

    17.0K

    Area of Science:

    • Biomedical Engineering
    • Electrical Engineering
    • Nanotechnology

    Background:

    • Cardiovascular diseases require sensitive and accurate diagnostic tools.
    • Cardiac Troponin I is a critical biomarker for diagnosing myocardial infarction.
    • Existing detection methods can be complex and time-consuming.

    Purpose of the Study:

    • To develop a highly sensitive pulse-stimulus sensor readout circuit for Cardiac Troponin I detection.
    • To integrate a gold nanoparticle-based sensor with a CMOS readout circuit.
    • To create a digital output for simplified analysis of cardiovascular disease biomarkers.

    Main Methods:

    • Fabrication of a gold nanoparticle plate with antibody post-modification for biomarker capture.
    • Utilization of gated pulses and transistor sensing to detect the electrostatic double-layer capacitor characteristics.
    • Integration of a current-to-frequency converter (I-to-F) and time-to-digital converter (TDC) for digital signal processing.
    • Implementation in a 0.18-μm standard CMOS process.

    Main Results:

    • Achieved a sensitivity of 1.77 Hz/pg-mL for Cardiac Troponin I detection.
    • Demonstrated a dynamic range of 72.43 dB.
    • The integrated circuit occupies a small area (0.92 mm²) and consumes low power (125 μW).

    Conclusions:

    • The proposed pulse-stimulus sensor readout circuit effectively detects Cardiac Troponin I.
    • The system offers high sensitivity and a wide dynamic range suitable for cardiovascular disease examinations.
    • The CMOS-integrated design presents a promising platform for point-of-care diagnostics.