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Related Experiment Video

Updated: Dec 6, 2025

Minimally-invasive Technique for Injection into Rat Optic Nerve

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

3D engineering for optic neuropathy treatment.

Wenjing Xuan¹, Aji Alex Moothedathu¹, Tuo Meng¹

¹Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.

Drug Discovery Today

|October 10, 2020

Summary

This summary is machine-generated.

This review explores 3D ocular tissue models for studying retinal degenerative diseases like AMD and glaucoma. These advanced models aid in developing new treatments for vision loss by enabling drug screening and mechanism studies.

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Area of Science:

Ophthalmology
Biomedical Engineering
Regenerative Medicine

Background:

Ocular disorders like AMD, DR, RP, and glaucoma cause irreversible vision loss, impacting millions.
Current 3D systems struggle to accurately mimic human ocular pathophysiology, particularly retinal degenerative diseases involving cell loss.

Purpose of the Study:

To review progress in 3D modeling of ocular tissues.
To examine the application of these models in optic neuropathy treatment, disease modeling, drug screening, and mechanistic studies.

Main Methods:

Literature review of current 3D ocular tissue modeling technologies.
Analysis of disease models for age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, and glaucoma.
Evaluation of applications in drug screening, mechanism studies, and cell/gene therapies.

Main Results:

Significant advancements in 3D ocular tissue modeling offer improved mimicry of human eye diseases.
These models are increasingly utilized for understanding disease mechanisms and evaluating potential therapies.
Applications span drug screening, basic research, and development of cell and gene therapies for optic neuropathies.

Conclusions:

3D ocular models represent a critical advancement in understanding and treating vision-threatening diseases.
Continued development and application of these models are essential for future therapeutic breakthroughs in ophthalmology.