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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Nursing Clinical Information System01:27

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
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Clinical Trials01:16

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

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The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
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Related Experiment Video

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Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
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Access Planning and Resource Coordination for Clinical Research Operations.

Jivan Deglise-Hawkinson1, David L Kaufman2, Blake Roessler3,4

  • 1Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, MI.

IISE Transactions
|October 12, 2020
PubMed
Summary

This study introduces the CApacity Planning Tool And INformatics (CAPTAIN) method to optimize clinical trial operations. CAPTAIN improves participant scheduling and resource allocation, reducing wait times and staff overtime costs for research sites.

Keywords:
Health Care OperationsMixed Integer ProgrammingPatient Flow ModelingProduction Planning and SchedulingStochastic Models

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Area of Science:

  • Operations Engineering
  • Clinical Research Management
  • Health Informatics

Background:

  • Clinical research sites face complex operational planning challenges due to time-sensitive, resource-specific trial protocols.
  • Current site planning and participant scheduling methods result in long, variable wait times (Time to First Available Visit - TFAV) and high staff overtime costs.

Purpose of the Study:

  • To develop an operations engineering and management methodology to optimize clinical trial site planning and coordination.
  • To introduce a decision support tool, CAPTAIN, for selecting valuable research trials and planning participant bookings within resource constraints.

Main Methods:

  • Developed CAPTAIN, integrating participant trajectory forecasting with an efficient visit booking reservation plan.
  • Utilized a Mixed Integer Program to estimate site metrics, optimizing daily nursing staff schedules alongside participant visit bookings.
  • Incorporated constraints such as staff overtime costs and TFAV by trial.

Main Results:

  • CAPTAIN provides decision support for optimizing the selection of research trials based on available resources.
  • The method generates a plan for booking participants' first visits, aiming to minimize TFAV and/or staff overtime.
  • Optimized daily nursing staff schedules are created to align with participant needs and resource availability.

Conclusions:

  • The CAPTAIN methodology offers a novel approach to enhance operational efficiency in clinical research settings.
  • This tool can help research sites better manage complex scheduling, reduce participant wait times, and control operational costs.