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Comorbidity of cerebellopontine angle meningioma with other primary neoplasms
Yi-Ting Xue1, Hsin-Lin Chen2,3, Yi-Ho Young1
1Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
Background:
Meningioma is known to be accompanied by other primary neoplasms, yet has been evaluated less than these.
Objective:
This study investigated comorbidity of cerebellopontine angle (CPA) meningioma with other primary neoplasms.
Methods:
Overall 1,085 meningioma cases including 16 meningiomas at the CPA were enrolled for investigating the presence of other primary neoplasms. Another 16 age-, sex-, and size-matched CPA schwannoma were also included for comparison.
Results:
Of a data-base cohort study of overall 1085 meningioma cases, 165 cases (15%) were associated with other primary neoplasms. In contrast, 8 (50%) of 16 CPA meningioma and one (8%) of 16 CPA schwannoma showed other primary neoplasms. Except for one patient who had oral cancer prior to the diagnosis of CPA meningioma by 4 years, the interval from diagnosis of CPA meningioma to that of other primary neoplasm ranged 0-6 (mean, 3.1 ± 2.5) years.
Conclusion:
Prevalence of comorbidity with other primary neoplasms is significantly higher in CPA meningioma (50%) than overall meningioma (15%) and CPA schwannoma (8%). In addition to follow-up MR imaging to visualize both residual tumor and regional brain environment after treatment of CPA meningioma, long-term systemic screening for other primary neoplasm is also mandatory.
