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Hydroxychloroquine in Hospitalized Patients with COVID-19: Real-World Experience Assessing Mortality
Frank H Annie1, Cristian Sirbu1, Keely R Frazier1
1Charleston Area Medical Center Health Education and Research Institute, Charleston, West Virginia, USA.
Pharmacotherapy
|October 12, 2020
Summary
Hydroxychloroquine (HCQ) did not increase 30-day mortality in hospitalized COVID-19 patients. This study found no significant difference in mortality or arrhythmias when using HCQ alone or with azithromycin (AZ).
Area of Science:
- Infectious Diseases
- Pharmacology
- Epidemiology
Background:
- Hydroxychloroquine (HCQ) has been investigated for treating coronavirus disease 2019 (COVID-19).
- Its use has been off-label or within clinical trials, necessitating real-world data analysis.
Purpose of the Study:
- To investigate the relationship between HCQ use and patient outcomes in COVID-19.
- To determine the effect of HCQ on all-cause mortality within 30 days of follow-up in hospitalized patients.
Main Methods:
- A retrospective cohort study utilizing a multinational database of COVID-19 patients.
- Propensity matching was employed to compare patients receiving HCQ within 48 hours of admission with those who did not.
- Data included medications, preexisting conditions, clinical measures, and outcomes.
Main Results:
- No statistically significant difference in 30-day all-cause mortality was observed between the HCQ and no-HCQ groups (13.1% vs. 13.6%).
- The combination of HCQ and azithromycin (AZ) did not show a statistically significant increase in mortality compared to no HCQ and AZ.
- No trend in overall mortality or arrhythmogenesis was found for the HCQ-AZ group versus the no HCQ-no AZ group.
Conclusions:
- Real-world data analysis indicates that HCQ use in hospitalized COVID-19 patients is not associated with a statistically significant increase in mortality.
- The combination of HCQ and AZ also did not demonstrate a significant increase in mortality or arrhythmogenesis.
- These findings contribute to understanding the safety profile of HCQ in COVID-19 treatment.
Keywords:
Antimalarialazithromycincoronavirushydroxychloroquinemacrolidesevere acute respiratory syndrome coronavirus 2More Related Videos
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