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Global immunoglobulin supply: steaming towards the iceberg?
Johan Prevot1, Stephen Jolles2
1IPOPI - International Patient Organisation for Primary Immunodeficiencies, Estoril, Portugal.
Current Opinion in Allergy and Clinical Immunology
|October 12, 2020
Summary
Global plasma supply faces challenges, with 65% collected in the US. Increased immunoglobulin use is driven by immunodeficiency diagnoses, while new therapies may impact future demand.
Area of Science:
- Plasma fractionation and its role in producing life-saving plasma-derived medicinal products (PDMPs).
- Analysis of global plasma supply dynamics and collection methods.
Background:
- Plasma-derived medicinal products (PDMPs) are crucial therapeutics.
- Understanding the sources of plasma, including recovered plasma and source plasma from plasmapheresis, is essential.
Purpose of the Study:
- To review plasma sourcing for PDMP fractionation.
- To compare recovered plasma and source plasma in the context of global supply.
- To identify growth areas and potential demand shifts for immunoglobulin therapies.
Main Methods:
- Review of existing literature on plasma sourcing and collection.
- Analysis of global plasma supply data, highlighting geographical distribution.
- Examination of trends in immunoglobulin use and emerging therapeutic alternatives.
Main Results:
- Significant geographical imbalance in plasma collection, with 65% sourced from the United States.
- Annual growth of 6-8% in immunoglobulin use, driven by immunodeficiency diagnoses.
- Emergence of neonatal Fc receptor inhibitors (FcRni) as potential disruptors of immunoglobulin demand.
Conclusions:
- Urgent need for increased and more geographically balanced plasma collection globally.
- Development of a regulated framework for both unpaid and compensated plasma donations is necessary.
- Ensuring patient access to life-saving PDMPs, donor care, and product safety are paramount considerations.
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