[Coagulopathy and COVID-19. Recommendations for a changing reality]

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Dardo Riveros1, Daniela Maymó1, Julia Laviano1

  • 1Servicio de Hematología, Medicina Transfusional y Trasplante de Médula ósea, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Buenos Aires, Argentina.

Medicina
|October 13, 2020
PubMed

Insights

Critically ill COVID-19 patients face increased risks of blood clots and organ failure due to a hypercoagulable state. This study reviews evidence to recommend treatments for coagulopathy, aiming to reduce COVID-19 patient mortality.

Area of Science:

  • Critical care medicine
  • Hematology
  • Infectious diseases

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with a significant risk of thromboembolic events.
  • Critically ill patients with SARS-CoV-2 infection exhibit a hypercoagulable state, evidenced by elevated D-dimer levels.
  • This hypercoagulability correlates with increased risks of organ failure and mortality.

Purpose of the Study:

  • To analyze the scientific evidence regarding the therapeutic management of coagulopathy in COVID-19.
  • To develop evidence-based recommendations for treating COVID-19-associated coagulopathy.
  • To reduce patient morbidity and mortality through optimized therapeutic strategies.

Main Methods:

  • Systematic review of available scientific literature.
  • Analysis of hemostatic abnormalities in SARS-CoV-2 infected patients.
  • Evidence synthesis for therapeutic decision-making.

Main Results:

  • COVID-19 induces a hypercoagulable state with elevated D-dimer.
  • Thromboembolism risk is elevated in critically ill COVID-19 patients.
  • Hemostatic abnormalities are critical factors in patient outcomes.

Conclusions:

  • Therapeutic decisions for COVID-19 patients must consider hemostasis abnormalities.
  • Evidence-based recommendations are crucial for managing coagulopathy.
  • Targeted interventions can potentially decrease COVID-19 morbidity and mortality.

Keywords:
COVID-19cytokine stormdisseminated intravascular coagulationheparinsepsis induced coagulopathythromboembolism

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